The NF1 gene encodes a gene product with 2810
amino acids, called neurofibromin. Between
amino acids 840 and 1200, this large protein
contains a domain that corresponds to a
GTPase-activating protein. The homology includes
a gene product in yeast (S. cerevisiae),
IRA1 (inhibitor of ras mutants). Mutations at
the NF1 locus interrupt a signal pathway to the
ras genes.
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